Notch one for activating NOTCH

Notch

The crux of development is that different cells need to be instructed to follow different developmental decisions. This involves signalling between cells so that each cell knows what its neighbour is doing. The Notch protein is pivotal for communication between cells during development and if Notch activity is perturbed, a cell may no longer be aware of which fate it should adopt. One consequen...

G9a controls placental vascular maturation by activating the Notch Pathway.

Defective fetoplacental vascular maturation causes intrauterine growth restriction (IUGR). A transcriptional switch initiates placental maturation, during which blood vessels elongate. However, the cellular mechanisms and regulatory pathways involved are unknown. We show that the histone methyltransferase G9a, also known as Ehmt2, activates the Notch pathway to promote placental vascular matura...

NOTCH 2 ( Notch homolog 2 ( Drosophila ) )

Kernohan’s Notch

James Collier, in 1904, gave one of the best early accounts of tonsillar herniation as a terminal event caused by raised intracranial pressure. He also observed false localizing signs. Adolf Meyer added to the picture, describing detailed pathology of tentorial and subfalcial herniation, and hemianopia as a false localizing sign. In 1929, Kernohan and Woltman published their important work on i...

Tuning NOTCH

The emergence of multi-cellular organs and their organization into complex body plans is a major cornerstone concerning origin of life on Earth. This requires that the fundamental unit of life, namely the cell, must communicate, coordinate and organize. Cell communication mediated by signal transduction pathways is essential for the development and functioning of any organism. About 20 differen...